OncoScore™ was developed based on the premise that gene expression patterns in cancer reflect the underlying biology of the tumor type and are therefore predictive and capable of stratifying patients based on prognosis or response to therapy.

BIOLOGICAL FUNCTION

The molecular heterogeneity of cancer can be reduced to a small number of core gene expression "modules" of biological function which correspond to cell lineage, pathway activation, de-regulation of a cellular process, genomic alterations or tumor microenvironment, enabling complex biological patterns to be reduced to a smaller set of representative genes.

For more information, visit the OncoScore web site.

OPTIMIZED FOR FFPE TISSUES

A key challenge in the development of gene expression-based assays and companion diagnostics is performing global gene expression profiling on formalin-fixed, paraffin-embedded "FFPE" clinical specimens and translating the resulting predictive signatures to clinical assays. Throughout the development process, we have leveraged AltheaDx's years of proven experience in developing, optimizing and validating real-time qPCR assays for FFPE samples to ensure quality data from sample types that are most practical for clinical research.